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Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate
https://sucra.repo.nii.ac.jp/records/13389
https://sucra.repo.nii.ac.jp/records/133891ac3365b-6bc1-4fe8-ad90-1096db388718
名前 / ファイル | ライセンス | アクション |
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A1002838.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-05-11 | |||||
タイトル | ||||||
タイトル | Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CHEMBIO | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PROTEINS | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fukuda, Isao
× Fukuda, Isao× Ito, Akihiro× Hirai, Go× Nishimura, Shinichi× Kawasaki, Hisashi× Saitoh, Hisato× Kimura, Ken-ichi× Sodeoka, Mikiko× 吉田, 稔 |
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著者 ローマ字 | ||||||
Fukuda, Isao | ||||||
著者 ローマ字 | ||||||
Ito, Akihiro | ||||||
著者 ローマ字 | ||||||
Hirai, Go | ||||||
著者 ローマ字 | ||||||
Nishimura, Shinichi | ||||||
著者 ローマ字 | ||||||
Kawasaki, Hisashi | ||||||
著者 ローマ字 | ||||||
Saitoh, Hisato | ||||||
著者 ローマ字 | ||||||
Kimura, Ken-ichi | ||||||
著者 ローマ字 | ||||||
Sodeoka, Mikiko | ||||||
著者 ローマ字 | ||||||
Yoshida, Minoru | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科 | ||||||
著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
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著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
Graduate School of Science and Engineering, Saitama University | ||||||
書誌情報 |
CHEMISTRY & BIOLOGY 巻 16, 号 2, p. 133-140, 発行日 2009 |
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年月次 | ||||||
2009-2 | ||||||
出版者名 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10745521 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.chembiol.2009.01.009 | |||||
関連サイト | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://www.sciencedirect.com/science/journal/10745521 | http://www.sciencedirect.com/science/journal/10745521 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Protein modification by small ubiquitin-related modifier proteins (SUMOs) controls diverse cellular functions. Dysregulation of SUMOylation or deSUMOylation processes has been implicated in the development of cancer and neurodegenerative diseases. However, no small-molecule inhibiting protein SUMOylation has been reported so far. Here, we report inhibition of SUMOylation by ginkgolic acid and its analog, anacardic acid. Ginkgolic acid and anacardic acid inhibit protein SUMOylation both in vitro and in vivo without affecting in vivo ubiquitination. Binding assays with a fluorescently labeled probe showed that ginkgolic acid directly binds El and inhibits the formation of the E1-SUMO intermediate. These studies will provide not only a useful tool for investigating the roles of SUMO conjugations in a variety of pathways in cells, but also a basis for the development of drugs targeted against diseases involving aberrant SUMOylation. | |||||
版 | ||||||
[著者版] | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2009-05-11 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A1002838 |