WEKO3
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Deletion of RAGE Causes Hyperactivity and Increased Sensitivity to Auditory Stimuli in Mice
https://sucra.repo.nii.ac.jp/records/14467
https://sucra.repo.nii.ac.jp/records/14467c1e10750-8d21-4a66-b931-2183678fc5c4
名前 / ファイル | ライセンス | アクション |
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A3000324.pdf (391.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-06-20 | |||||
タイトル | ||||||
タイトル | Deletion of RAGE Causes Hyperactivity and Increased Sensitivity to Auditory Stimuli in Mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
酒谷, 誠一
× 酒谷, 誠一× 山田, 一之× 本間, 千尋× 棟居, 聖一× 山本, 靖彦× 山本, 博× 平瀬, 肇 |
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著者 ローマ字 | ||||||
SAKATANI, Seiichi | ||||||
著者 ローマ字 | ||||||
YAMADA, Kazuyuki | ||||||
著者 ローマ字 | ||||||
HOMMA, Chihiro | ||||||
著者 ローマ字 | ||||||
MUNESUE, Seiichi | ||||||
著者 ローマ字 | ||||||
YAMAMOTO, Yasuhiko | ||||||
著者 ローマ字 | ||||||
YAMAMOTO, Hiroshi | ||||||
著者 ローマ字 | ||||||
Hirase Hajime | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター平瀬肇研究ユニット | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター研究基盤センター | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター研究基盤センター | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター平瀬肇研究ユニット, 埼玉大学脳科学融合研究センター | ||||||
著者 所属(別言語) | ||||||
Hirase Research Unit, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Research Resource Center, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Research Resource Center, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science | ||||||
著者 所属(別言語) | ||||||
Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science | ||||||
著者 所属(別言語) | ||||||
Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science | ||||||
著者 所属(別言語) | ||||||
Hirase Research Unit, RIKEN Brain Science Institute, Saitama University Brain Science Institute | ||||||
書誌情報 |
PLoS ONE 巻 4, 号 12, p. 1-7, 発行日 2009 |
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年月次 | ||||||
2009-12 | ||||||
出版者名 | ||||||
出版者 | Public Library of Science (PLoS) | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1371/journal.pone.0008309 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | e8309 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor that belongs to the immunoglobulin superfamily of cell surface receptors. In diabetes and Alzheimer’s disease, pathological progression is accelerated by activation of RAGE. However, how RAGE influences gross behavioral activity patterns in basal condition has not been addressed to date. In search for a functional role of RAGE in normal mice, a series of standard behavioral tests were performed on adult RAGE knockout (KO) mice. We observed a solid increase of home cage activity in RAGE KO. In addition, auditory startle response assessment resulted in a higher sensitivity to auditory signal and increased prepulse inhibition in KO mice. There were no significant differences between KO and wild types in behavioral tests for spatial memory and anxiety, as tested by Morris water maze, classical fear conditioning, and elevated plus maze. Our results raise a possibility that systemic therapeutic treatments to occlude RAGE activation may have adverse effects on general activity levels or sensitivity to auditory stimuli. | |||||
版 | ||||||
[出版社版] | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2011-06-20 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A3000324 |