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A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7
https://sucra.repo.nii.ac.jp/records/13044
https://sucra.repo.nii.ac.jp/records/130444f503971-ddb3-48ce-9456-153917f48400
名前 / ファイル | ライセンス | アクション |
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A1002389.pdf (644.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-16 | |||||
タイトル | ||||||
タイトル | A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Saccharomyces cerevisiae | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mitochondria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA-damage response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transcriptional regulation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
吉谷, 綾子
× 吉谷, 綾子× 吉田, 稔 |
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著者 ローマ字 | ||||||
Yoshitani, Ayako | ||||||
著者 ローマ字 | ||||||
Yoshida, Minoru | ||||||
著者 ローマ字 | ||||||
Ling, Feng | ||||||
著者 所属 | ||||||
独立行政法人理化学研究所 | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科 | ||||||
著者 所属(別言語) | ||||||
Chemical Genetics Laboratory, RIKEN Discovery Research Institute | ||||||
著者 所属(別言語) | ||||||
Graduate School of Science and Engineering, Saitama University | ||||||
書誌情報 |
Biochemical and Biophysical Research Communications 巻 365, 号 1, p. 183-188, 発行日 2008 |
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年月次 | ||||||
2008 | ||||||
出版者名 | ||||||
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006291X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.bbrc.2007.10.177 | |||||
関連サイト | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://www.sciencedirect.com/science/journal/0006291X | http://www.sciencedirect.com/science/journal/0006291X | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Din7 is a DNA damage-inducible mitochondrial nuclease that modulates the stability of mitochondrial DNA (mtDNA) in Saccharomyces cerevisiae. How DIN7 gene expression is regulated, however, has remained largely unclear. Using promoter sequence alignment, we found a highly conserved 19-bp sequence in the promoter regions of DIN7 and NTG1, which encodes an oxidative stress-inducible base-excision-repair enzyme. Deletion of the 19-bp sequence markedly reduced the hydroxyurea (HU)-enhanced DIN7 promoter activity. In addition, nuclear fractions prepared from HU-treated cells were used in in vitro band shift assays to reveal the presence of currently unidentified trans-acting factor(s) that preferentially bound to the 19-bp region. These results suggest that the 19-bp sequence is a novel cis-acting element that is required for the regulation of DIN7 expression in response to HU-induced DNA damage. (c) 2007 Elsevier Inc. All rights reserved. | |||||
目次 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ・本文.fdf.pdf ・Supplementary data.fdf.pdf |
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版 | ||||||
[著者版] | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2008-01-16 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A1002389 |