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Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR.
https://sucra.repo.nii.ac.jp/records/13131
https://sucra.repo.nii.ac.jp/records/131317369b79a-5123-4fea-832a-d2de7cf68d3d
名前 / ファイル | ライセンス | アクション |
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A1002463.pdf (863.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-03-06 | |||||
タイトル | ||||||
タイトル | Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiangiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antitumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epoxyquinoid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VEGF | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
神山, 洋
× 神山, 洋× Kakeya, H× Usui, T× Nishikawa, K× Shoji, M× Hayashi, Y× 長田, 裕之 |
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著者 ローマ字 | ||||||
Kamiyama, Hiroshi | ||||||
著者 ローマ字 | ||||||
Kakeya, H | ||||||
著者 ローマ字 | ||||||
Usui, T | ||||||
著者 ローマ字 | ||||||
Nishikawa, K | ||||||
著者 ローマ字 | ||||||
Shoji, M | ||||||
著者 ローマ字 | ||||||
Hayashi, Y | ||||||
著者 ローマ字 | ||||||
Osada, Hiroyuki | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科博士後期課程(理化学研究所長田抗生物質研究室所属) | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
埼玉大学大学院 | ||||||
著者 所属(別言語) | ||||||
Graduate School of Science and Engineering, Saitama University | ||||||
書誌情報 |
Oncology Research 巻 17, 号 1, p. 11-21, 発行日 2008 |
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年月次 | ||||||
2008 | ||||||
出版者名 | ||||||
出版者 | Cognizant Communication Corporation | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09650407 | |||||
関連サイト | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://www.cognizantcommunication.com/filecabinet/Oncology/onc.htm | http://www.cognizantcommunication.com/filecabinet/Oncology/onc.htm | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Angiogenesis is the development of new blood vessels to provide oxygen and nutrients and is indispensable for solid tumor growth. Therefore, the inhibition of angiogenesis is an important modality for cancer chemotherapy. Here we report the antiangiogenic mechanism and antitumor effects of epoxyquinol B (EPQB), which was isolated from fungal metabolites. Short term treatment of EPQB resulted in the reduction of tumor growth and the number of blood vessels directed to the tumor in a murine xenografts model. Furthermore, EPQB inhibited vascular endothelial growth factor (VEGF) -induced migration and tube formation in human umbilical vein endothelial cells (HUVECs) without cytotoxicity in vitro. VEGF-stimulated phosphorylation of VEGF receptor 2 (VEGFR2), phospholipase C ?-1 (PLC?1), and p44/42 MAP kinases (ERK) was inhibited by EPQB in a dose-dependent manner, and in vitro assay using kinase domain of VEGFR2 showed that EPQB covalently bound and inhibited the VEGFR2 kinase. Its binding site on VEGFR2 was different from SU5614, a well-known VEGFR2 kinase inhibitor. Interestingly, EPQB inhibited growth factor-induced activation of not only VEGFR2 but also epidermal growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR), and platelet-derived growth factor receptor (PDGFR), suggesting that EPQB is a novel multiple kinase inhibitor. These findings suggest that EPQB would be a good lead compound for the development of potent antiangiogenic and anti-tumor drugs. | |||||
版 | ||||||
[著者版] | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2008-03-06 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A1002463 |