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Activator-to-repressor conversion of T-box transcription factors by the ripply family of Groucho/TLE-associated mediators
https://sucra.repo.nii.ac.jp/records/13262
https://sucra.repo.nii.ac.jp/records/13262ebd144ef-bf1c-4453-b080-59661f1c5131
名前 / ファイル | ライセンス | アクション |
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A1002644.pdf (4.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-05-27 | |||||
タイトル | ||||||
タイトル | Activator-to-repressor conversion of T-box transcription factors by the ripply family of Groucho/TLE-associated mediators | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
川村, 哲規
× 川村, 哲規 |
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著者 ローマ字 | ||||||
Kawamura, Akinori | ||||||
著者 ローマ字 | ||||||
Koshida, Sumito | ||||||
著者 ローマ字 | ||||||
Takada, Shinji | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科生命科学部門 | ||||||
著者 所属(別言語) | ||||||
Department of Life Science, Graduate School of Science and Engineering, Saitama University | ||||||
書誌情報 |
MOLECULAR AND CELLULAR BIOLOGY 巻 28, 号 10, p. 3236-3244, 発行日 2008 |
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年月次 | ||||||
2008-5 | ||||||
出版者名 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02707306 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1128/MCB.01754-07 | |||||
関連サイト | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://mcb.asm.org/cgi/content/abstract/28/10/3236 | http://mcb.asm.org/cgi/content/abstract/28/10/3236 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The T-box family of transcription factors, defined by a conserved DNA binding domain called the T-box, regulate various aspects of embryogenesis by activating and/or repressing downstream genes. In spite of the biological significance of the T-box proteins, how they regulate transcription remains to be elucidated. Here we show that the Groucho/TLE-associated protein Ripply converts T-box proteins from activators to repressors. In cultured cells, zebrafish Ripply1, an essential component in somite segmentation, and its structural relatives, Ripply2 and -3, suppress the transcriptional activation mediated by the T-box protein Tbx24, which is coexpressed with ripply1 during segmentation. Ripply1 associates with Tbx24 and converts it to a repressor. Ripply1 also antagonizes the transcriptional activation of another T-box protein, No tail (Ntl), the zebrafish ortholog of Brachyury. Furthermore, injection of a high dosage of ripply1 mRNA into zebrafish eggs causes defective development of the posterior trunk, similar to the phenotype observed in homozygous mutants of ntl. A mutant form of Ripply1 defective in association with Tbx24 also lacks activity in zebrafish embryos. These results indicate that the intrinsic transcriptional property of T-box proteins is controlled by Ripply family proteins, which act as specific adaptors that recruit the global corepressor Groucho/TLE to T-box proteins. | |||||
版 | ||||||
[著者版] | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2008-05-27 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A1002644 |