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Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1
https://sucra.repo.nii.ac.jp/records/13307
https://sucra.repo.nii.ac.jp/records/13307033ed8e0-bd75-4610-b77d-97e062e56425
名前 / ファイル | ライセンス | アクション |
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A1002749.pdf (347.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-07-25 | |||||
タイトル | ||||||
タイトル | Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p38 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p62 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Paget's disease of bone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | safety catch | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawai, Kayoko
× Kawai, Kayoko× Saito, Akiko× Sudo, Tatsuhiko× 長田, 裕之 |
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著者 ローマ字 | ||||||
Kawai, Kayoko | ||||||
著者 ローマ字 | ||||||
Saito, Akiko | ||||||
著者 ローマ字 | ||||||
Sudo, Tatsuhiko | ||||||
著者 ローマ字 | ||||||
Osada, Hiroyuki | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
埼玉大大学院理工学研究科 | ||||||
著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
著者 所属(別言語) | ||||||
Graduate School of Science and Engineering, Saitama University | ||||||
書誌情報 |
JOURNAL OF BIOCHEMISTRY 巻 143, 号 6, p. 765-772, 発行日 2008 |
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年月次 | ||||||
2008-6 | ||||||
出版者名 | ||||||
出版者 | 社団法人日本生化学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021924X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1093/jb/mvn027 | |||||
関連サイト | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://jb.oxfordjournals.org/cgi/content/full/143/6/765 | http://jb.oxfordjournals.org/cgi/content/full/143/6/765 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have previously shown that p62/SQSTM1 binds to p38. In this study, we identified two association domains of p62 to p38 by conducting co-immunoprecipitation experiments. One domain comprises the amino acids 173182, named N-terminal p38 interaction (NPI) domain, and the other domain comprises the amino acids 335344, named C-terminal p38 interaction (CPI) domain. An aspartic acid tripeptide located at 335337 was required for their association. However, the direct interaction was only observed between the recombinant p38 and the peptide of the NPI domain, but not that of the CPI domain in the surface plasmon resonance analyses. These results suggest that the CPI domain may serve to form a certain conformation suitable for the association with p38. Furthermore, we showed that knockdown of p62 expression by siRNA led to impaired p38 phosphorylation only when HeLa cells were stimulated by cytokine. The critical role of p62 in cytokine-dependent p38 signalling pathway was further confirmed by measuring IL-8 mRNA. Cytokine mRNA is often stabilized via p38 pathway. In the absence of p62, IL-8 mRNA induced by IL-1 became more fragile. These data show that p62 specifically regulates cytokine-dependent p38 signalling pathway. | |||||
版 | ||||||
[出版社版] | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2008-07-25 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A1002749 |