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In Vivo Intracellular Recording Suggests That Gray Matter Astrocytes in Mature Cerebral Cortex and Hippocampus Are Electrophysiologically Homogeneous
https://sucra.repo.nii.ac.jp/records/14470
https://sucra.repo.nii.ac.jp/records/14470294f1cf4-44c2-45e9-a267-9f575ffa27e2
名前 / ファイル | ライセンス | アクション |
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A3000332.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-07-15 | |||||
タイトル | ||||||
タイトル | In Vivo Intracellular Recording Suggests That Gray Matter Astrocytes in Mature Cerebral Cortex and Hippocampus Are Electrophysiologically Homogeneous | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
三嶋, 恒子
× 三嶋, 恒子× 平瀬, 肇 |
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著者 ローマ字 | ||||||
MISHIMA, Tsuneko | ||||||
著者 ローマ字 | ||||||
HIRASE, Hajime | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター平瀬肇研究ユニット | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター平瀬肇研究ユニット, 埼玉大学脳科学融合研究センター | ||||||
著者 所属(別言語) | ||||||
Hirase Research Unit, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Hirase Research Unit, RIKEN Brain Science Institute・Saitama University Brain Science Institute | ||||||
書誌情報 |
The Journal of Neuroscience 巻 30, 号 8, p. 3093-3100, 発行日 2010 |
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年月次 | ||||||
2010-2 | ||||||
出版者名 | ||||||
出版者 | Society for Neuroscience | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02706474 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1523/JNEUROSCI.5065-09.2010 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Previous anatomical and in vitro electrophysiology studies suggest that astrocytes are heterogeneous in physiology, morphology, and biochemical content. However, the extent to which this diversity applies to in vivo conditions is largely unknown. To characterize and classify the physiological and morphological properties of cerebral cortical and hippocampal astrocytes in the intact brain, we performed in vivo intracellular recordings from single astrocytes using anesthetized mature rats. Astrocytes were classified based on their glial fibrillary acidic protein (GFAP) immunoreactivity and cell body locations. We analyzed morphometric measures such as the occupied volume and polarity, as well as physiological characteristics such as the mean membrane potential. These measurements did not show obvious segregation into subpopulations, suggesting that gray matter astrocytes in the cortex and hippocampus are composed of a homogeneous population in mature animals. The membrane potential of astrocytes in both cortex and hippocampus fluctuated within a few millivolts in the presence of spontaneous network activity. These membrane potential fluctuations of an astrocyte showed a significant variability that depended on the local field potential state and cell body location. We attribute the variability of the membrane potential fluctuations to local potassium concentration changes due to neuronal activity. | |||||
版 | ||||||
[出版社版] | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2011-07-15 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A3000332 |