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["進化実験系の解析・評価技術・適応歩行技術の研究 : 中立ネットワークの探査と進化戦略の検討"], "weko_shared_id": -1}
進化実験系の解析・評価技術・適応歩行技術の研究 : 中立ネットワークの探査と進化戦略の検討
https://doi.org/10.24561/00016612
https://doi.org/10.24561/00016612c0b799fe-cc31-4d0d-bcc2-82e0ab4c1add
名前 / ファイル | ライセンス | アクション |
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KY-AA11808968-02-11.pdf (164.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2009-06-02 | |||||
タイトル | ||||||
タイトル | 進化実験系の解析・評価技術・適応歩行技術の研究 : 中立ネットワークの探査と進化戦略の検討 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Experimental molecular evolution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein conformation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sequence space | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.24561/00016612 | |||||
ID登録タイプ | JaLC | |||||
タイトル(別言語) | ||||||
その他のタイトル | An in silico Exploration of the Neutral Network in Protein Sequence Space and Evolution Strategy | |||||
著者 |
相田, 拓洋
× 相田, 拓洋× 伏見, 譲 |
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著者 ローマ字 | ||||||
Aita, Takuyo | ||||||
著者 ローマ字 | ||||||
Husimi, Yuzuru | ||||||
著者 所属 | ||||||
ノバルティスファーマ(株)筑波研究所 | ||||||
著者 所属 | ||||||
埼玉大学工学部機能材料工学科 | ||||||
著者 所属(別言語) | ||||||
Novartis Pharma K.K. | ||||||
著者 所属(別言語) | ||||||
Saitama University | ||||||
書誌情報 |
埼玉大学地域共同研究センター紀要 en : Report of Cooperative Research Center, Saitama University 巻 2, p. 37-39, 発行日 2002 |
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年月次 | ||||||
2001 | ||||||
出版者名 | ||||||
出版者 | 埼玉大学地域共同研究センター | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13474758 | |||||
概要 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Considering that many amino acid sequences that fold into a common main chain structure form a percolation network in protein sequence space, we call the network "neutral network" for the structure. The neutral evolution is regarded as a walk on the neutral network. If a network for a structure A and a network for another structure B intersect each other in a special region in a sequence space, the walker can exchange one network to another network. That is, the evolving protein can change its shape from structure A to B and vise versa by accepting several mutations. Schultes et al. confirmed the existence of the neutral paths in the RNA sequence space in their experiment (Schultes & Bartel, 2000). For four distinct target structures (α, β, α/β and α+β-types ) with the same chain length of 108, we investigated whether there is the corresponding neutral network in the sequence space by using computer simulation. An exploring walk simulation suggested that the neutral network spans over the sequence space. Through another exploring walk simulation, we investigated contiguous regions between or among the neutral networks for the distinct protein structures and obtained the results that the closest approach distance between the two neutral networks ranged from 5 to 29 on the Hamming distance scale. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2009-06-18 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
KY-AA11808968-02-11 |