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Astrocytes as a target of transcranial direct current stimulation (tDCS) to treat depression
https://sucra.repo.nii.ac.jp/records/18338
https://sucra.repo.nii.ac.jp/records/1833863b9388e-4acb-4ed8-afc9-f42daaa3a372
名前 / ファイル | ライセンス | アクション |
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A3000438.pdf (418.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-08-17 | |||||
タイトル | ||||||
タイトル | Astrocytes as a target of transcranial direct current stimulation (tDCS) to treat depression | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
毛内, 拡
× 毛内, 拡× 平瀬, 肇 |
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著者 ローマ字 | ||||||
MONAI, Hiromu | ||||||
著者 ローマ字 | ||||||
HIRASE, Hajime | ||||||
著者 所属 | ||||||
RIKEN Brain Science Institute | ||||||
著者 所属 | ||||||
RIKEN Brain Science Institute, Brain and Body System Science Institute, Saitama University | ||||||
書誌情報 |
Neuroscience Research 巻 126, p. 15-21, 発行日 2018 |
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年月次 | ||||||
2018-1 | ||||||
出版者名 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01680102 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.neures.2017.08.012 | |||||
関連サイト | ||||||
内容記述タイプ | Other | |||||
内容記述 | https://doi.org/10.1016/j.neures.2017.08.012 | https://doi.org/10.1016/j.neures.2017.08.012 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Transcranial direct current stimulation (tDCS) has been reported to be effective in treating mood disorders such as major depressive disorder, however, its detailed mechanism of action is not fully understood. Human and animal experiments have demonstrated that tDCS promotes brain plasticity and have suggested that this consequence may underlie its therapeutic benefits. Nonetheless, the specific neurobiological underpinnings of tDCS-induced brain plasticity have only recently begun to be investigated. While brain plasticity occurs in synapses formed by neurons, astrocytes, a major glial cell type, have recently been shown to support synaptic plasticity via intracellular Ca2+ signaling. In this perspective article, we discuss our recent results demonstrating that tDCS induces the activation of astrocytic calcium signaling that constitutes a required component for treating chronic restraint stress-induced depressive mice. We put forward the notion that activation of astrocytic Ca2+ signaling could be used clinically as a potent remedy for depression. | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Special Issue on Astrocytes as therapeutic targets in brain disease models | |||||
版 | ||||||
[著者版] | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2018-08-17 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A3000438 |