{"created":"2023-05-15T15:25:01.352784+00:00","id":12484,"links":{},"metadata":{"_buckets":{"deposit":"64262dc2-6323-4dc5-b2ad-933b7c338f3a"},"_deposit":{"created_by":3,"id":"12484","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"12484"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00012484","sets":["94:426"]},"author_link":["19550"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"19","bibliographicVolumeNumber":"186","bibliographic_titles":[{"bibliographic_title":"Journal of bacteriology"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-03-05","subitem_date_issued_type":"Created"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lethal effect of the Escherichia coli pgsA null mutation which causes a complete lack of the major acidic phospholipids, phosphatidylglycerol and cardiolipin, is alleviated by the lack of the major outer membrane lipoprotein encoded by the lpp gene, but the lpp pgsA strain shows a thermosensitive growth defect. By transposon mutagenesis we found that the hermosensitivity was suppressed by disruption of the rcsC, rcsF, and yojN genes that code for sensor kinase, accessory positive factor, and phosphotransmitter, respectively, of the Rcs phosphorelay signal transduction system initially identified as regulating the capsular polysaccharide synthesis genes (cps). Disruption of the rcsB gene coding for the response regulator of the system also suppressed the thermosensitivity, whereas disruption of cpsE did not. By monitoring the expression of a cpsB′-lac fusion we showed the Rcs system was activated in the pgsA mutant and reversed to a wild-type level by the rcs mutations. These results indicate that the envelope stress due to acidic phospholipid deficiency activates the Rcs phosphorelay system and thereby causes the thermosensitive growth defect independently of the activation of capsule synthesis.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1128/JB.186.19.6526-6535.2004","subitem_relation_type_select":"DOI"}}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Hara, Hiroshi"},{"subitem_text_value":"Shiba, Yasuhiro"},{"subitem_text_value":"Yokoyama, Yasuko"},{"subitem_text_value":"Aono, Yoshiko"},{"subitem_text_value":"Kiuchi, Takashi"},{"subitem_text_value":"Kusaka, Jin"},{"subitem_text_value":"Matsumoto, Kouji"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A1002021"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"埼玉大学大学院理工学研究科"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"Saitama University, Graduate School of Science and Engineering"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2004"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原, 弘志"},{"creatorName":"ハラ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A1002021.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A1002021.pdf","url":"https://sucra.repo.nii.ac.jp/record/12484/files/A1002021.pdf"},"version_id":"0be00b33-7eba-4bd7-9717-46ccabed147a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activation of the rcs signal transduction system is responsible for the thermosensitive growth defect of an Escherichia coli mutant lacking phosphatidylglycerol and cardiolipin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation of the rcs signal transduction system is responsible for the thermosensitive growth defect of an Escherichia coli mutant lacking phosphatidylglycerol and cardiolipin"}]},"item_type_id":"119","owner":"3","path":["426"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-03-08"},"publish_date":"2007-03-08","publish_status":"0","recid":"12484","relation_version_is_last":true,"title":["Activation of the rcs signal transduction system is responsible for the thermosensitive growth defect of an Escherichia coli mutant lacking phosphatidylglycerol and cardiolipin"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T13:03:36.931794+00:00"}