{"created":"2023-05-15T15:25:25.209060+00:00","id":13044,"links":{},"metadata":{"_buckets":{"deposit":"83345484-1d6f-4e2b-81a4-89183780d6b8"},"_deposit":{"created_by":3,"id":"13044","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13044"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00013044","sets":["94:426"]},"author_link":["20825","20824"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"188","bibliographicPageStart":"183","bibliographicVolumeNumber":"365","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-01-16","subitem_date_issued_type":"Created"}]},"item_119_description_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/0006291X | http://www.sciencedirect.com/science/journal/0006291X","subitem_description_type":"Other"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Din7 is a DNA damage-inducible mitochondrial nuclease that modulates the stability of mitochondrial DNA (mtDNA) in Saccharomyces cerevisiae. How DIN7 gene expression is regulated, however, has remained largely unclear. Using promoter sequence alignment, we found a highly conserved 19-bp sequence in the promoter regions of DIN7 and NTG1, which encodes an oxidative stress-inducible base-excision-repair enzyme. Deletion of the 19-bp sequence markedly reduced the hydroxyurea (HU)-enhanced DIN7 promoter activity. In addition, nuclear fractions prepared from HU-treated cells were used in in vitro band shift assays to reveal the presence of currently unidentified trans-acting factor(s) that preferentially bound to the 19-bp region. These results suggest that the 19-bp sequence is a novel cis-acting element that is required for the regulation of DIN7 expression in response to HU-induced DNA damage. (c) 2007 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_119_description_20":{"attribute_name":"目次","attribute_value_mlt":[{"subitem_description":"・本文.fdf.pdf\n・Supplementary data.fdf.pdf\n","subitem_description_type":"Other"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"ACADEMIC PRESS INC ELSEVIER SCIENCE"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.bbrc.2007.10.177","subitem_relation_type_select":"DOI"}}]},"item_119_source_id_14":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[著者版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Yoshitani, Ayako"},{"subitem_text_value":"Yoshida, Minoru"},{"subitem_text_value":"Ling, Feng"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A1002389"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"独立行政法人理化学研究所"},{"subitem_text_value":"埼玉大学大学院理工学研究科"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"Chemical Genetics Laboratory, RIKEN Discovery Research Institute"},{"subitem_text_value":"Graduate School of Science and Engineering, Saitama University"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2008"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉谷, 綾子"},{"creatorName":"ヨシタニ, アヤコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉田, 稔"},{"creatorName":"ヨシダ, ミノル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A1002389.pdf","filesize":[{"value":"644.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A1002389.pdf","url":"https://sucra.repo.nii.ac.jp/record/13044/files/A1002389.pdf"},"version_id":"8255f738-d93a-494c-9fde-e1f75c46bca2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Saccharomyces cerevisiae","subitem_subject_scheme":"Other"},{"subitem_subject":"Mitochondria","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA-damage response","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcriptional regulation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7"}]},"item_type_id":"119","owner":"3","path":["426"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-16"},"publish_date":"2008-01-16","publish_status":"0","recid":"13044","relation_version_is_last":true,"title":["A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T12:42:13.851093+00:00"}