{"created":"2023-05-15T15:25:33.957642+00:00","id":13251,"links":{},"metadata":{"_buckets":{"deposit":"cb1d145c-3363-41d9-bdee-8b071e492bcc"},"_deposit":{"created_by":3,"id":"13251","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13251"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00013251","sets":["94:426"]},"author_link":["21331","21327","21330","21329","21332","21328","21326","21325"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"97","bibliographicPageStart":"94","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Journal of Antibiotics"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-05-13","subitem_date_issued_type":"Created"}]},"item_119_description_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_description":"http://www.jstage.jst.go.jp/article/antibiotics/61/2/61_94/_article/-char/ja/ | http://www.jstage.jst.go.jp/article/antibiotics/61/2/61_94/_article/-char/ja/","subitem_description_type":"Other"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epoxyquinol B (EPQB) is a fungal metabolite, containing two ???-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues of receptor kinases. However, the inhibitory mechanism was undefined. In this report, we found that one EPQB molecule is covalently bound to two L-cysteine molecules through two epoxide residues on EPQB. Furthermore, EPQB crosslinked binding proteins through the cysteine residues. These results suggest that EPQB inhibits receptor kinases by crosslinking with other protein or by intramolecular crosslinking.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"財団法人日本抗生物質学術協議会"}]},"item_119_source_id_14":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00218820","subitem_source_identifier_type":"ISSN"}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[著者版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kamiyama, Hiroshi"},{"subitem_text_value":"Usui, Takeo"},{"subitem_text_value":"Uramoto, Masakazu"},{"subitem_text_value":"Takagi, Hiroshi"},{"subitem_text_value":"Shoji, Mitsuru"},{"subitem_text_value":"Hayashi, Yujiro"},{"subitem_text_value":"Kakeya, Hideaki"},{"subitem_text_value":"Osada, Hiroyuki"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A1002464"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"埼玉大学大学院理工学研究科博士後期課程(理化学研究所長田抗生物質研究室所属)"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"埼玉大学大学院"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Science and Engineering, Saitama University"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2008-2"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"神山, 洋"},{"creatorName":"カミヤマ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, Takeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uramoto, Masakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takagi, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shoji, Mitsuru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Yujiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kakeya, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長田, 裕之"},{"creatorName":"オサダ, ヒロユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A1002464.pdf","filesize":[{"value":"244.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A1002464.pdf","url":"https://sucra.repo.nii.ac.jp/record/13251/files/A1002464.pdf"},"version_id":"0670219d-6957-434c-8b14-0bfdda1f10c7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Epoxyquinol B","subitem_subject_scheme":"Other"},{"subitem_subject":"crosslink","subitem_subject_scheme":"Other"},{"subitem_subject":"epoxide","subitem_subject_scheme":"Other"},{"subitem_subject":"epoxyquinoid","subitem_subject_scheme":"Other"},{"subitem_subject":"fungal metabolite","subitem_subject_scheme":"Other"},{"subitem_subject":"cysteine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation"}]},"item_type_id":"119","owner":"3","path":["426"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-05-13"},"publish_date":"2008-05-13","publish_status":"0","recid":"13251","relation_version_is_last":true,"title":["Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T19:18:28.833840+00:00"}