{"created":"2023-05-15T15:25:36.705827+00:00","id":13316,"links":{},"metadata":{"_buckets":{"deposit":"6e0a6fc6-2a29-455b-95a2-957a9be3767b"},"_deposit":{"created_by":3,"id":"13316","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13316"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00013316","sets":["94:426"]},"author_link":["21581","21580","21584","21582","21585","21586","21583","21587","21579"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6896","bibliographicPageEnd":"442","bibliographicPageStart":"438","bibliographicVolumeNumber":"418","bibliographic_titles":[{"bibliographic_title":"NATURE"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-08-20","subitem_date_issued_type":"Created"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control(1-3). Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCFFbx2) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-linked high-mannose oligosaccharides and subsequently contributes to ubiquitination of N-glycosylated proteins. Pre-integrin beta1 is a target of Fbx2; these two proteins interact in the cytosol after inhibition of the proteasome. In addition, expression of the mutant Fbx2DeltaF, which lacks the F-box domain that is essential for forming the SCF complex, appreciably blocks degradation of typical substrates of the ER-associated degradation pathway(5,6). Our results indicate that SCFFbx2 ubiquitinates N-glycosylated proteins that are translocated from the ER to the cytosol by the quality control mechanism.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/nature00890","subitem_relation_type_select":"DOI"}}]},"item_119_source_id_14":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00280836","subitem_source_identifier_type":"ISSN"}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[著者版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Yoshida, Y"},{"subitem_text_value":"Chiba, T"},{"subitem_text_value":"Tokunaga, F"},{"subitem_text_value":"Kawasaki, H"},{"subitem_text_value":"Iwai, K"},{"subitem_text_value":"Suzuki, T"},{"subitem_text_value":"Ito, Y"},{"subitem_text_value":"Matsuoka, K"},{"subitem_text_value":"Yoshida, Minoru"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A1002757"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"埼玉大学大学院理工学研究科生命科学部門"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Graduate School of Science and Engineering, Saitama University"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2002-7"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chiba, T"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokunaga, F"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawasaki, H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwai, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, T"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuoka, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉田, 稔"},{"creatorName":"ヨシダ, ミノル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A1002757.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A1002757.pdf","url":"https://sucra.repo.nii.ac.jp/record/13316/files/A1002757.pdf"},"version_id":"af9a7f2a-0788-4cf0-b1cc-88b9af4e67bb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"E3 ubiquitin ligase that recognizes sugar chains","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"E3 ubiquitin ligase that recognizes sugar chains"}]},"item_type_id":"119","owner":"3","path":["426"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-19"},"publish_date":"2008-08-19","publish_status":"0","recid":"13316","relation_version_is_last":true,"title":["E3 ubiquitin ligase that recognizes sugar chains"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T19:16:08.650017+00:00"}