@article{oai:sucra.repo.nii.ac.jp:00013344,
 author = {相田, 拓洋 and 伏見, 譲},
 issue = {1},
 journal = {JOURNAL OF THEORETICAL BIOLOGY},
 month = {},
 note = {http://www.sciencedirect.com/science/journal/00225193 | http://www.sciencedirect.com/science/journal/00225193, The NK fitness landscape is a mathematical landscape model with a parameter k that governs the degree of ruggedness of the landscape. We presented a procedure to fit a given landscape to the NK fitness landscape by introducing the "apparent k-value" k(app). In this paper, we defined the protein free energy (Delta G) landscape in amino acid sequence space, where Delta G is the folding free energy from a random coil to a "certain conformation". Applying this landscape to our fitting procedure, we examined the statistical properties of the landscape. For calculation of a conformation energy, amino acid residues are represented by points, and interaction energies among amino acid residues are given as (1 + K)-body interactions, that is, an unit of interacting (1 + K) residues cooperatively contribute a single energy value to the conformational energy. Our results suggest that the apparent k-value of the free energy landscape is k(app) approximate to K, and that the number of possible interactions among residues is unrelated to the k(app) value. This leads to the inference that k(app) takes values about 1-3 in real landscapes, if nature adopts two-body similar to four-body interaction energies. (c) 2008 Elsevier Ltd. All rights reserved., text, application/pdf},
 pages = {151--161},
 title = {Fitting protein-folding free energy landscape for a certain conformation to an NK fitness landscape},
 volume = {253},
 year = {2008},
 yomi = {アイタ, タクヨウ and フシミ, ユズル}
}