{"created":"2023-05-15T15:25:37.885539+00:00","id":13344,"links":{},"metadata":{"_buckets":{"deposit":"f8d657b3-6ac0-4e31-9dc7-ccab73c8b0df"},"_deposit":{"created_by":3,"id":"13344","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13344"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00013344","sets":["94:426"]},"author_link":["21629","21630"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"161","bibliographicPageStart":"151","bibliographicVolumeNumber":"253","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF THEORETICAL BIOLOGY"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-20","subitem_date_issued_type":"Created"}]},"item_119_description_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/00225193 | http://www.sciencedirect.com/science/journal/00225193","subitem_description_type":"Other"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The NK fitness landscape is a mathematical landscape model with a parameter k that governs the degree of ruggedness of the landscape. We presented a procedure to fit a given landscape to the NK fitness landscape by introducing the \"apparent k-value\" k(app). In this paper, we defined the protein free energy (Delta G) landscape in amino acid sequence space, where Delta G is the folding free energy from a random coil to a \"certain conformation\". Applying this landscape to our fitting procedure, we examined the statistical properties of the landscape. For calculation of a conformation energy, amino acid residues are represented by points, and interaction energies among amino acid residues are given as (1 + K)-body interactions, that is, an unit of interacting (1 + K) residues cooperatively contribute a single energy value to the conformational energy. Our results suggest that the apparent k-value of the free energy landscape is k(app) approximate to K, and that the number of possible interactions among residues is unrelated to the k(app) value. This leads to the inference that k(app) takes values about 1-3 in real landscapes, if nature adopts two-body similar to four-body interaction energies. (c) 2008 Elsevier Ltd. All rights reserved.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.jtbi.2008.02.034","subitem_relation_type_select":"DOI"}}]},"item_119_source_id_14":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00225193","subitem_source_identifier_type":"ISSN"}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[著者版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Aita, Takuyo"},{"subitem_text_value":"HUSIMI, Yuzuru"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A1002788"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"産業技術総合研究所生命情報科学研究センター(現 : 埼玉大学大学院理工学研究科)"},{"subitem_text_value":"埼玉大学工学部機能材料工学科"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"Rational Evolutionary Design of Advanced Biomolecules(REDS) Group/JST, Saitama Small Enterprise Promotion Corporation SKIP City(Present : Graduate School of Science and Engineering, Saitama University)"},{"subitem_text_value":"Department of Functional Materials Science, Saitama University"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2008-7"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"相田, 拓洋"},{"creatorName":"アイタ, タクヨウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伏見, 譲"},{"creatorName":"フシミ, ユズル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A1002788.pdf","filesize":[{"value":"282.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A1002788.pdf","url":"https://sucra.repo.nii.ac.jp/record/13344/files/A1002788.pdf"},"version_id":"f48e797e-52f6-45e2-aa13-23eea8edfd22"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"fitness landscape","subitem_subject_scheme":"Other"},{"subitem_subject":"sequence space","subitem_subject_scheme":"Other"},{"subitem_subject":"canonical ensemble","subitem_subject_scheme":"Other"},{"subitem_subject":"NK model","subitem_subject_scheme":"Other"},{"subitem_subject":"in vitro evolution","subitem_subject_scheme":"Other"},{"subitem_subject":"in silica evolution","subitem_subject_scheme":"Other"},{"subitem_subject":"thermostability","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fitting protein-folding free energy landscape for a certain conformation to an NK fitness landscape","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fitting protein-folding free energy landscape for a certain conformation to an NK fitness landscape"}]},"item_type_id":"119","owner":"3","path":["426"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-21"},"publish_date":"2008-10-21","publish_status":"0","recid":"13344","relation_version_is_last":true,"title":["Fitting protein-folding free energy landscape for a certain conformation to an NK fitness landscape"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T12:37:03.014022+00:00"}