{"created":"2023-05-15T15:25:37.928513+00:00","id":13345,"links":{},"metadata":{"_buckets":{"deposit":"72c74fe1-4430-4957-91e3-0ace3be00d34"},"_deposit":{"created_by":3,"id":"13345","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13345"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00013345","sets":["94:426"]},"author_link":["21633","28925","21634","28926","21631","21632"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"550","bibliographicPageStart":"538","bibliographicVolumeNumber":"246","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF THEORETICAL BIOLOGY"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-20","subitem_date_issued_type":"Created"}]},"item_119_description_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/00225193 | http://www.sciencedirect.com/science/journal/00225193","subitem_description_type":"Other"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have developed a methodology for extracting characteristic properties of a fitness landscape of interest by analyzing fitness data on an in vitro molecular evolution. The in vitro evolution is required to be conducted as the following '' adaptive walk '': a single parent sequence generates N mutant sequences as its offsprings, and the fittest individual among the N offsprings will become a new parent in the next generation. N is the library size of mutants to be screened in a single generation. Our theory of the adaptive walk on the '' NK landscape '' suggests the following: the adaptive walker starting from a random sequence climbs the landscape easily in an early stage, and then reaches a stationary phase in which the mutation-selection-random drift balance sets in. The stationary fitness value is nearly proportional to root In N. Our analysis is performed from the following points: (1) stationary fitness values, (2) time series of fitness in the transitional state, (3) mutant's fitness distribution, and (4) the strength of selection pressure. Applying our methodology, we analyzed experimental data on the in vitro evolution of a random polypeptide (139 amino acids) toward acquiring infectivity (= ability to infect) of fd phage. As a result, we estimated that k is about 27 in this system, indicating that an arbitrary residue in a sequence is affected from other 23% residues. In this article, we demonstrated that the experimental data is consistent with our theoretical equations quantitatively, and that our methodology for extracting characteristic properties of a fitness landscape may be effective. (C) 2007 Elsevier Ltd. All rights reserved.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.jtbi.2006.12.037","subitem_relation_type_select":"DOI"}}]},"item_119_source_id_14":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00225193","subitem_source_identifier_type":"ISSN"}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[著者版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Aita, Takuyo"},{"subitem_text_value":"Hayashi, Yuuki"},{"subitem_text_value":"Toyota, Hitoshi"},{"subitem_text_value":"Husimi, Yuzuru"},{"subitem_text_value":"Urabe, Itaru"},{"subitem_text_value":"Yomo, Tetsuya"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A1002789"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"産業技術総合研究所生命情報科学研究センター(現 : 埼玉大学大学院理工学研究科)"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"埼玉大学工学部機能材料工学科"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"Rational Evolutionary Design of Advanced Biomolecules(REDS) Group/JST, Saitama Small Enterprise Promotion Corporation SKIP City(Present : Graduate School of Science and Engineering, Saitama University)"},{"subitem_text_value":"Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University"},{"subitem_text_value":"Department of Biotechnology, Graduate School of Engineering, Osaka University"},{"subitem_text_value":"Department of Functional Materials Science, Saitama University"},{"subitem_text_value":"Department of Biotechnology, Graduate School of Engineering, Osaka University"},{"subitem_text_value":"Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2007-6"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"相田, 拓洋"},{"creatorName":"アイタ, タクヨウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Yuuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toyota, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伏見, 譲"},{"creatorName":"フシミ, ユズル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Urabe, Itaru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yomo, Tetsuya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A1002789.pdf","filesize":[{"value":"252.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A1002789.pdf","url":"https://sucra.repo.nii.ac.jp/record/13345/files/A1002789.pdf"},"version_id":"25076eea-8dcf-4623-8327-cd0ac3c9c48a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"fitness landscape","subitem_subject_scheme":"Other"},{"subitem_subject":"sequence space","subitem_subject_scheme":"Other"},{"subitem_subject":"adaptive walk","subitem_subject_scheme":"Other"},{"subitem_subject":"NK model","subitem_subject_scheme":"Other"},{"subitem_subject":"in vitro evolution","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Extracting Characteristic Properties of Fitness Landscape from In Vitro Molecular Evolution: A Case Study on Infectivity of fd Phage to E.coli.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Extracting Characteristic Properties of Fitness Landscape from In Vitro Molecular Evolution: A Case Study on Infectivity of fd Phage to E.coli."}]},"item_type_id":"119","owner":"3","path":["426"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-21"},"publish_date":"2008-10-21","publish_status":"0","recid":"13345","relation_version_is_last":true,"title":["Extracting Characteristic Properties of Fitness Landscape from In Vitro Molecular Evolution: A Case Study on Infectivity of fd Phage to E.coli."],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T19:15:36.742109+00:00"}