{"created":"2023-05-15T15:25:38.016909+00:00","id":13347,"links":{},"metadata":{"_buckets":{"deposit":"da624607-fc7c-414e-8aca-3208ee8454c2"},"_deposit":{"created_by":3,"id":"13347","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13347"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00013347","sets":["94:426"]},"author_link":["21638","21637"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"228","bibliographicPageStart":"215","bibliographicVolumeNumber":"225","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF THEORETICAL BIOLOGY"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-20","subitem_date_issued_type":"Created"}]},"item_119_description_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/00225193 | http://www.sciencedirect.com/science/journal/00225193","subitem_description_type":"Other"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have theoretically studied the statistical properties of adaptive walks (or hill-climbing) on a Mt. Fuji-type fitness landscape in the multi-dimensional sequence space through mathematical analysis and computer simulation. The adaptive walk is characterized by the \"mutation distance\" d as the step-width of the walker and the \"population size\" N as the number of randomly generated d-fold point mutants to be screened. In addition to the fitness W, we introduced the following quantities analogous to thermodynamical concepts: \"free fitness\" G(W) drop W + T x S(W), where T is the \"evolutionary temperature\" T proportional to rootd/lnN and S(W) is the entropy as a function of W, and the \"evolutionary force\" X drop d(G(W)/T)/dW, that is caused by the mutation and selection pressure. It is known that a single adaptive walker rapidly climbs on the fitness landscape up to the stationary state where a \"mutation-selection-random drift balance\" is kept. In our interpretation, the walker tends to the maximal free fitness state, driven by the evolutionary force X. Our major findings are as follows: First, near the stationary point W*, the \"climbing rate\" J as the expected fitness change per generation is described by J approximate to L x X with L approximate to V/2, where V is the variance of fitness distribution on a local landscape. This simple relationship is analogous to the well-known Einstein relation in Brownian motion. Second, the \"biological information gain\" (DeltaG/T) through adaptive walk can be described by combining the Shannon's information gain (DeltaS) and the \"fitness information gain\" (DeltaW/T). (C) 2003 Elsevier Ltd. All rights reserved.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/S0022-5193(03)00240-6","subitem_relation_type_select":"DOI"}}]},"item_119_source_id_14":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00225193","subitem_source_identifier_type":"ISSN"}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[著者版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Aita, Takuyo"},{"subitem_text_value":"HUSIMI, Yuzuru"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A1002791"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"産業技術総合研究所生命情報科学研究センター(現 : 埼玉大学大学院理工学研究科)"},{"subitem_text_value":"埼玉大学工学部機能材料工学科"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology(Present : Graduate School of Science and Engineering, Saitama University)"},{"subitem_text_value":"Department of Functional Materials Science, Saitama University"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2003-11"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"相田, 拓洋"},{"creatorName":"アイタ, タクヨウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伏見, 譲"},{"creatorName":"フシミ, ユズル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A1002791.pdf","filesize":[{"value":"252.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A1002791.pdf","url":"https://sucra.repo.nii.ac.jp/record/13347/files/A1002791.pdf"},"version_id":"427ee59b-4370-4e5c-9e31-fc07b5c3420a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"free fitness","subitem_subject_scheme":"Other"},{"subitem_subject":"fluctuation-dissipation theorem","subitem_subject_scheme":"Other"},{"subitem_subject":"information","subitem_subject_scheme":"Other"},{"subitem_subject":"molecular evolution","subitem_subject_scheme":"Other"},{"subitem_subject":"sequence space","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thermodynamical Interpretation of an Adaptive Walk on a Mt. Fuji-type Fitness Landscape: Einstein Relation-like Formula Holds in a Stochastic Evolution","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thermodynamical Interpretation of an Adaptive Walk on a Mt. Fuji-type Fitness Landscape: Einstein Relation-like Formula Holds in a Stochastic Evolution"}]},"item_type_id":"119","owner":"3","path":["426"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-21"},"publish_date":"2008-10-21","publish_status":"0","recid":"13347","relation_version_is_last":true,"title":["Thermodynamical Interpretation of an Adaptive Walk on a Mt. Fuji-type Fitness Landscape: Einstein Relation-like Formula Holds in a Stochastic Evolution"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T12:37:01.141689+00:00"}