@article{oai:sucra.repo.nii.ac.jp:00013437,
 author = {Fukuda, Isao and Ito, Akihiro and Uramoto, Masakazu and Saitoh, Hisato and Kawasaki, Hisashi and 長田, 裕之 and 吉田, 稔},
 issue = {4},
 journal = {JOURNAL OF ANTIBIOTICS},
 month = {},
 note = {http://www.nature.com/ja/journal/v62/n4/abs/ja200910a.html | http://www.nature.com/ja/journal/v62/n4/abs/ja200910a.html, Protein SUMOylation has recently been shown as one of the major post-translational modifications involved in a variety of signaling pathways in cells. In the course of our screening program using an in situ SUMOylation-detecting system, kerriamycin B, which had been originally isolated as an antibiotic, was identified as a novel inhibitor of protein SUMOylation. Kerriamycin B inhibits both in vitro and in vivo protein SUMOylation by blocking the formation of the E1-SUMO intermediate. Our findings will provide not only a novel tool for investigating the role of SUMO conjugations but also useful information for developing therapeutic drugs., text, application/pdf},
 pages = {221--224},
 title = {Kerriamycin B inhibits protein SUMOylation},
 volume = {62},
 year = {2009},
 yomi = {オサダ, ヒロユキ and ヨシダ, ミノル}
}