{"created":"2023-05-15T15:26:27.723338+00:00","id":14467,"links":{},"metadata":{"_buckets":{"deposit":"ffb24d1e-f9f1-46c5-b0c4-9e2782499113"},"_deposit":{"created_by":3,"id":"14467","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14467"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00014467","sets":["95:242"]},"author_link":["24808","24810","24807","24811","24805","24806","24809"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-06-20","subitem_date_issued_type":"Created"}]},"item_119_description_18":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"e8309","subitem_description_type":"Other"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor that belongs to the immunoglobulin superfamily of cell surface receptors. In diabetes and Alzheimer’s disease, pathological progression is accelerated by activation of RAGE. However, how RAGE influences gross behavioral activity patterns in basal condition has not been addressed to date. In search for a functional role of RAGE in normal mice, a series of standard behavioral tests were performed on adult RAGE knockout (KO) mice. We observed a solid increase of home cage activity in RAGE KO. In addition, auditory startle response assessment resulted in a higher sensitivity to auditory signal and increased prepulse inhibition in KO mice. There were no significant differences between KO and wild types in behavioral tests for spatial memory and anxiety, as tested by Morris water maze, classical fear conditioning, and elevated plus maze. Our results raise a possibility that systemic therapeutic treatments to occlude RAGE activation may have adverse effects on general activity levels or sensitivity to auditory stimuli.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science (PLoS)"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1371/journal.pone.0008309","subitem_relation_type_select":"DOI"}}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[出版社版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"SAKATANI, Seiichi"},{"subitem_text_value":"YAMADA, Kazuyuki"},{"subitem_text_value":"HOMMA, Chihiro"},{"subitem_text_value":"MUNESUE, Seiichi"},{"subitem_text_value":"YAMAMOTO, Yasuhiko"},{"subitem_text_value":"YAMAMOTO, Hiroshi"},{"subitem_text_value":"Hirase Hajime"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A3000324"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"理化学研究所脳科学総合研究センター平瀬肇研究ユニット"},{"subitem_text_value":"理化学研究所脳科学総合研究センター研究基盤センター"},{"subitem_text_value":"理化学研究所脳科学総合研究センター研究基盤センター"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"理化学研究所脳科学総合研究センター平瀬肇研究ユニット, 埼玉大学脳科学融合研究センター"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"Hirase Research Unit, RIKEN Brain Science Institute"},{"subitem_text_value":"Research Resource Center, RIKEN Brain Science Institute"},{"subitem_text_value":"Research Resource Center, RIKEN Brain Science Institute"},{"subitem_text_value":"Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science"},{"subitem_text_value":"Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science"},{"subitem_text_value":"Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science"},{"subitem_text_value":"Hirase Research Unit, RIKEN Brain Science Institute, Saitama University Brain Science Institute"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2009-12"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"酒谷, 誠一"},{"creatorName":"サカタニ, セイイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 一之"},{"creatorName":"ヤマダ, カズユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本間, 千尋"},{"creatorName":"ホンマ, チヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"棟居, 聖一"},{"creatorName":"ムネスエ, セイイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 靖彦"},{"creatorName":"ヤマモト, ヤスヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 博"},{"creatorName":"ヤマモト, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平瀬, 肇"},{"creatorName":"ヒラセ, ハジメ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A3000324.pdf","filesize":[{"value":"391.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A3000324.pdf","url":"https://sucra.repo.nii.ac.jp/record/14467/files/A3000324.pdf"},"version_id":"4f9b38f7-4db4-4d41-8709-8688ea2d0e7c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Deletion of RAGE Causes Hyperactivity and Increased Sensitivity to Auditory Stimuli in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Deletion of RAGE Causes Hyperactivity and Increased Sensitivity to Auditory Stimuli in Mice"}]},"item_type_id":"119","owner":"3","path":["242"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-20"},"publish_date":"2011-06-20","publish_status":"0","recid":"14467","relation_version_is_last":true,"title":["Deletion of RAGE Causes Hyperactivity and Increased Sensitivity to Auditory Stimuli in Mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:57:07.805596+00:00"}