{"created":"2023-05-15T15:26:27.976958+00:00","id":14473,"links":{},"metadata":{"_buckets":{"deposit":"77f77ff2-59a0-4fa4-afb0-96b85c4eb5e4"},"_deposit":{"created_by":3,"id":"14473","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14473"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00014473","sets":["95:242"]},"author_link":["24839","24844","24843","24841","24842","24840","24838"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"49","bibliographicPageEnd":"18165","bibliographicPageStart":"18155","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"The Journal of Neuroscience"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-06-06","subitem_date_issued_type":"Created"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Global brain state dynamics regulate plasticity in local cortical circuits, but the underlying cellular and molecular mechanisms are unclear. Here, we demonstrate that astrocyte Ca2+ signaling provides a critical bridge between cholinergic activation, associated with attention and vigilance states, and somatosensory plasticity in mouse barrel cortex in vivo. We investigated first whether a combined stimulation of mouse whiskers and the nucleus basalis of Meynert (NBM), the principal source of cholinergic innervation to the cortex, leads to enhanced whisker-evoked local field potential. This plasticity is dependent on muscarinic acetylcholine receptors (mAChR) and N-methyl-d-aspartic acid receptors (NMDARs). During the induction of this synaptic plasticity, we find that astrocytic [Ca2+] is pronouncedly elevated, which is blocked by mAChR antagonists. The elevation of astrocytic [Ca2+] is crucial in this type of synaptic plasticity, as the plasticity could not be induced in inositol-1,4,5-trisphosphate receptor type 2 knock-out (IP3R2-KO) mice, in which astrocytic [Ca2+] surges are diminished. Moreover, NBM stimulation led to a significant increase in the extracellular concentration of the NMDAR coagonist d-serine in wild-type mice when compared to IP3R2-KO mice. Finally, plasticity in IP3R2-KO mice could be rescued by externally supplying d-serine. Our data present coherent lines of in vivo evidence for astrocytic involvement in cortical plasticity. These findings suggest an unexpected role of astrocytes as a gate for cholinergic plasticity in the cortex.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"Society for Neuroscience"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1523/JNEUROSCI.5289-11.2011","subitem_relation_type_select":"DOI"}}]},"item_119_source_id_14":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02706474","subitem_source_identifier_type":"ISSN"}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[出版社版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"TANAKA, Norio"},{"subitem_text_value":"MISHIMA, Tsuneko"},{"subitem_text_value":"HISATSUNE, Chihiro"},{"subitem_text_value":"NAGAI, Terumi"},{"subitem_text_value":"EBISUI, Etsuko"},{"subitem_text_value":"MIKOSHIBA, Katsuhiko"},{"subitem_text_value":"HIRASE, Hajime"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A3000337"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"理化学研究所脳科学総合研究センター神経グリア回路研究チーム"},{"subitem_text_value":"理化学研究所脳科学総合研究センター神経グリア回路研究チーム"},{"subitem_text_value":"理化学研究所脳科学総合研究センター発生神経生物研究チーム"},{"subitem_text_value":"理化学研究所脳科学総合研究センター神経グリア回路研究チーム"},{"subitem_text_value":"理化学研究所脳科学総合研究センター発生神経生物研究チーム"},{"subitem_text_value":"理化学研究所脳科学総合研究センター発生神経生物研究チーム, 科学技術振興機構"},{"subitem_text_value":"理化学研究所脳科学総合研究センター神経グリア回路研究チーム, 埼玉大学脳科学融合研究センター"}]},"item_119_text_5":{"attribute_name":"著者 所属(別言語)","attribute_value_mlt":[{"subitem_text_value":"Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute"},{"subitem_text_value":"Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute"},{"subitem_text_value":"Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute"},{"subitem_text_value":"Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute"},{"subitem_text_value":"Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute"},{"subitem_text_value":"Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute･ICORP-SORST JST"},{"subitem_text_value":"Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute・Saitama University Brain Science Institute"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2011-12"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高田, 則雄"},{"creatorName":"タナカ, ノリオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三嶋, 恒子"},{"creatorName":"ミシマ, ツネコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久恒, 智博"},{"creatorName":"ヒサツネ, チヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"永井, てるみ"},{"creatorName":"ナガイ, テルミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"戎井, 悦子"},{"creatorName":"エビスイ, エツオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"御子柴, 克彦"},{"creatorName":"ミコシバ, カツヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平瀬, 肇"},{"creatorName":"ヒラセ, ハジメ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A3000337.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A3000337.pdf","url":"https://sucra.repo.nii.ac.jp/record/14473/files/A3000337.pdf"},"version_id":"2d609676-d389-4c10-bafa-29148e1b087f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo"}]},"item_type_id":"119","owner":"3","path":["242"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-04"},"publish_date":"2012-06-04","publish_status":"0","recid":"14473","relation_version_is_last":true,"title":["Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:57:06.795460+00:00"}