{"created":"2023-05-15T15:26:28.186038+00:00","id":14478,"links":{},"metadata":{"_buckets":{"deposit":"53237bd9-8ee2-478b-b6f8-88b5addec2f6"},"_deposit":{"created_by":3,"id":"14478","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14478"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00014478","sets":["95:242"]},"author_link":["24860","24863","24862","24861"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"236","bibliographicPageStart":"229","bibliographicVolumeNumber":"295","bibliographic_titles":[{"bibliographic_title":"Neuroscience"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-12-14","subitem_date_issued_type":"Created"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The striatum is a major target of cerebral cortical output. The cortico-striatal projection has been well described, however, the neurochemical changes that occur in the striatum after prolonged cortical hyperactivation remain to be investigated. In this study, extracellular levels of glutamate, GABA, and alanine levels were measured in the dorsal striatum using microdialysis in anesthetized mice at resting condition and during 4-aminopyridine (4-AP)-induced cortical seizures. After topical application of 4-AP on the primary motor cortex that induced cortical seizures, the extracellular level of striatal GABA increased by 40% in sixty minutes. By contrast, the extracellular level of striatal glutamate decreased by 20%. Moreover, the surface amounts of striatal glutamate/aspartate transporter (GLAST) and glutamate transporter 1(GLT-1), the major astrocytic high-affinity glutamate transporters, tended to increase by cortical seizures in 60 min, suggesting a recruitment of the glutamate transporters from internal stores. 4-AP also resulted in a steady increase of alanine levels which are thought to reflect glutamate and pyruvate metabolism in neurons and astrocytes. These observations possibly delineate adaptive changes of striatal metabolism by severe cortical seizures.","subitem_description_type":"Abstract"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.neuroscience.2015.03.043","subitem_relation_type_select":"DOI"}}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[著者版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"NAGAI, Terumi"},{"subitem_text_value":"TAKATA, Norio"},{"subitem_text_value":"SHINOHARA, Yoshiaki"},{"subitem_text_value":"HIRASE, Hajime"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A3000423"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"RIKEN Brain Science Institute"},{"subitem_text_value":"RIKEN Brain Science Institute, Department of Neuropsychiatry, School of Medicine, Keio University"},{"subitem_text_value":"RIKEN Brain Science Institute"},{"subitem_text_value":"RIKEN Brain Science Institute, Saitama University Brain Science Institute"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2015-6"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永井, てるみ"},{"creatorName":"ナガイ, テルミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高田, 則雄"},{"creatorName":"タカタ, ノリオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"篠原, 良章"},{"creatorName":"シノハラ, ヨシアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平瀬, 肇"},{"creatorName":"ヒラセ, ハジメ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-24"}],"displaytype":"detail","filename":"A3000423.pdf","filesize":[{"value":"746.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A3000423.pdf","url":"https://sucra.repo.nii.ac.jp/record/14478/files/A3000423.pdf"},"version_id":"2b51d540-27d7-409f-9e78-2829b9bd371c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HPLC","subitem_subject_scheme":"Other"},{"subitem_subject":"GLT-1","subitem_subject_scheme":"Other"},{"subitem_subject":"GLAST","subitem_subject_scheme":"Other"},{"subitem_subject":"basal ganglia","subitem_subject_scheme":"Other"},{"subitem_subject":"cortical seizures","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures"}]},"item_type_id":"119","owner":"3","path":["242"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-14"},"publish_date":"2017-12-14","publish_status":"0","recid":"14478","relation_version_is_last":true,"title":["Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T11:56:46.900015+00:00"}