@article{oai:sucra.repo.nii.ac.jp:00016082,
 author = {幡野, 健 and 松岡, 浩司 and 照沼, 大陽},
 journal = {埼玉大学紀要. 工学部 第1編 第1部 論文集, The Science and Engineering Reports of Saitama University},
 month = {},
 note = {Carbosilane dendrimer periphery bearing globotiaose were synthesized by SN2 reaction of thiolate anion at aglycon of globotriaose and brominated carbosilane dendrimer. Binding assay of tree shapes of carbosilane dendrimers [Fan(0)3, Dumbbell(1)6 and Ball(1)12] were carried out. Vero toxin classified into two closely related subgroups, Stx1 and Stx2. Dumbbell(1)6 and Ball(1)12 markedly inhibited the cytotoxic activity of both Stx1 (0.22 and 0.16 μg/ml respectively) and Stx2 (2.3 and 1.3 μg/ml, respectively) toward Vero cells; whereas the IC50 of Fan(0)3 was more than 100 μg/ml. The result of the binding assay of these toxins suggested that Dumbbell(1)6 and Ball(1)12 bind to both Stx1 and Stx2 with high affinities. Furthermore, inhibitory effects of these dendrimers on the lethality of intravenously administered Stx2 in mice were investigated. Dumbbell(1)6 completely suppressed the lethal effect of Stx2 when administered along with the toxin. The dendrimer treated mice survived more than 2 months without any pathological symptoms., text, application/pdf},
 pages = {40--44},
 title = {カルボシランデンドリマー・糖鎖複合材料の開発 : 大腸菌O157の産生するベロ毒素中和剤への応用<論文>},
 volume = {38},
 year = {2005},
 yomi = {ハタノ, ケン and マツオカ, コウジ and テルヌマ, ダイヨウ}
}