{"created":"2023-05-15T15:28:56.721291+00:00","id":18338,"links":{},"metadata":{"_buckets":{"deposit":"95b3d83b-a606-46d1-a92a-7a335fb8fc81"},"_deposit":{"created_by":3,"id":"18338","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18338"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00018338","sets":["95:242"]},"author_link":["29373","29372"],"item_119_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"21","bibliographicPageStart":"15","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"Neuroscience Research"}]}]},"item_119_date_31":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-08-17","subitem_date_issued_type":"Created"}]},"item_119_description_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_description":"https://doi.org/10.1016/j.neures.2017.08.012 | https://doi.org/10.1016/j.neures.2017.08.012","subitem_description_type":"Other"}]},"item_119_description_19":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Transcranial direct current stimulation (tDCS) has been reported to be effective in treating mood disorders such as major depressive disorder, however, its detailed mechanism of action is not fully understood. Human and animal experiments have demonstrated that tDCS promotes brain plasticity and have suggested that this consequence may underlie its therapeutic benefits. Nonetheless, the specific neurobiological underpinnings of tDCS-induced brain plasticity have only recently begun to be investigated. While brain plasticity occurs in synapses formed by neurons, astrocytes, a major glial cell type, have recently been shown to support synaptic plasticity via intracellular Ca2+ signaling. In this perspective article, we discuss our recent results demonstrating that tDCS induces the activation of astrocytic calcium signaling that constitutes a required component for treating chronic restraint stress-induced depressive mice. We put forward the notion that activation of astrocytic Ca2+ signaling could be used clinically as a potent remedy for depression.","subitem_description_type":"Abstract"}]},"item_119_description_21":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Special Issue on Astrocytes as therapeutic targets in brain disease models","subitem_description_type":"Other"}]},"item_119_description_29":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_119_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_119_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_119_relation_16":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.neures.2017.08.012","subitem_relation_type_select":"DOI"}}]},"item_119_source_id_14":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01680102","subitem_source_identifier_type":"ISSN"}]},"item_119_text_27":{"attribute_name":"版","attribute_value_mlt":[{"subitem_text_value":"[著者版]"}]},"item_119_text_3":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"MONAI, Hiromu"},{"subitem_text_value":"HIRASE, Hajime"}]},"item_119_text_32":{"attribute_name":"アイテムID","attribute_value_mlt":[{"subitem_text_value":"A3000438"}]},"item_119_text_4":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"RIKEN Brain Science Institute"},{"subitem_text_value":"RIKEN Brain Science Institute, Brain and Body System Science Institute, Saitama University"}]},"item_119_text_9":{"attribute_name":"年月次","attribute_value_mlt":[{"subitem_text_value":"2018-1"}]},"item_119_version_type_28":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"毛内, 拡"},{"creatorName":"モウナイ, ヒロム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平瀬, 肇"},{"creatorName":"ヒラセ, ハジメ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-17"}],"displaytype":"detail","filename":"A3000438.pdf","filesize":[{"value":"418.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"A3000438.pdf","url":"https://sucra.repo.nii.ac.jp/record/18338/files/A3000438.pdf"},"version_id":"3111d641-22e4-4497-ab96-04e82725349d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Astrocytes as a target of transcranial direct current stimulation (tDCS) to treat depression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Astrocytes as a target of transcranial direct current stimulation (tDCS) to treat depression"}]},"item_type_id":"119","owner":"3","path":["242"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-08-17"},"publish_date":"2018-08-17","publish_status":"0","recid":"18338","relation_version_is_last":true,"title":["Astrocytes as a target of transcranial direct current stimulation (tDCS) to treat depression"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T19:00:27.896771+00:00"}