{"created":"2023-05-15T15:29:49.992385+00:00","id":19688,"links":{},"metadata":{"_buckets":{"deposit":"95e609d3-83b5-40c4-8865-01c20b3ad067"},"_deposit":{"created_by":15,"id":"19688","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"19688"},"status":"published"},"_oai":{"id":"oai:sucra.repo.nii.ac.jp:00019688","sets":["94:429:431:432:1028"]},"author_link":[],"item_113_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"}}]},"item_113_date_35":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-10-07","subitem_date_issued_type":"Created"}]},"item_113_date_granted_20":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-22"}]},"item_113_degree_grantor_22":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"埼玉大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"12401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_113_degree_name_21":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(理学)"}]},"item_113_description_13":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_description":"60p","subitem_description_type":"Other"}]},"item_113_description_24":{"attribute_name":"目次","attribute_value_mlt":[{"subitem_description":"第1章 序論\n　　　第1節 序 ····················································································· 1\n\n第2章 Kinanthraquinone (KQ) 生合成遺伝子クラスターの同定 ·························· 3\n　　　第1節 KQ生合成遺伝子クラスターの探索 ········································· 3\n　　　第2節 異種発現ベクターの構築及び形質転換株の解析 ························· 8\n　　　第3節 kiqG遺伝子破壊株の解析 ······················································ 9\n　　　第4節 非典型OmpRファミリー制御因子遺伝子 ································· 10\n　　　第5節 kiqA遺伝子発現によるKQ類縁体の生産性改善 ························ 12\n　　　第6節 KQ類縁体の構造決定 ·························································· 13\n　　　第7節 Feeding実験によるKQBからKQへの変換 ······························ 16\n　　　第8節 考察 ····················································································· 17\n\n第3章 KQ生合成遺伝子クラスターの解析と新規化合物の生物活性評価 ············· 18\n　　　第1節 遺伝子破壊と生合成中間体の解析 ·········································· 18\n　　　第2節 kiqO遺伝子破壊株に蓄積した化合物の単離・構造決定 ·············· 20\n　　　第3節 Feeding実験による6,9-DHTからKQへの変換 ······························ 23\n　　　第4節 6,9-DHTの生物活性評価 ······················································· 24\n　　　第5節 配糖化経路の探索 ······························································· 25\n　　　第6節 考察 ················································································· 27\n\n実験の部 ···································································································· 29\n参考文献 ···································································································· 39\n補遺 ·········································································································· 46\n謝辞 ·········································································································· 59","subitem_description_type":"Other"}]},"item_113_description_25":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"主指導教員 : 高橋俊二","subitem_description_type":"Other"}]},"item_113_description_33":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_113_description_34":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_113_dissertation_number_19":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1214号"}]},"item_113_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24561/00019657","subitem_identifier_reg_type":"JaLC"}]},"item_113_publisher_11":{"attribute_name":"出版者名","attribute_value_mlt":[{"subitem_publisher":"埼玉大学大学院理工学研究科"}]},"item_113_publisher_12":{"attribute_name":"出版者名（別言語）","attribute_value_mlt":[{"subitem_publisher":"Graduate School of Science and Engineering, Saitama 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