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Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation
https://sucra.repo.nii.ac.jp/records/13251
https://sucra.repo.nii.ac.jp/records/13251c5cd16b8-5ce8-4613-bb9c-8238f5518342
名前 / ファイル | ライセンス | アクション |
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A1002464.pdf (244.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-05-13 | |||||
タイトル | ||||||
タイトル | Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epoxyquinol B | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | crosslink | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epoxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epoxyquinoid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fungal metabolite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cysteine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
神山, 洋
× 神山, 洋× Usui, Takeo× Uramoto, Masakazu× Takagi, Hiroshi× Shoji, Mitsuru× Hayashi, Yujiro× Kakeya, Hideaki× 長田, 裕之 |
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著者 ローマ字 | ||||||
Kamiyama, Hiroshi | ||||||
著者 ローマ字 | ||||||
Usui, Takeo | ||||||
著者 ローマ字 | ||||||
Uramoto, Masakazu | ||||||
著者 ローマ字 | ||||||
Takagi, Hiroshi | ||||||
著者 ローマ字 | ||||||
Shoji, Mitsuru | ||||||
著者 ローマ字 | ||||||
Hayashi, Yujiro | ||||||
著者 ローマ字 | ||||||
Kakeya, Hideaki | ||||||
著者 ローマ字 | ||||||
Osada, Hiroyuki | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科博士後期課程(理化学研究所長田抗生物質研究室所属) | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
著者 所属 | ||||||
埼玉大学大学院 | ||||||
著者 所属(別言語) | ||||||
Graduate School of Science and Engineering, Saitama University | ||||||
書誌情報 |
Journal of Antibiotics 巻 61, 号 2, p. 94-97, 発行日 2008 |
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年月次 | ||||||
2008-2 | ||||||
出版者名 | ||||||
出版者 | 財団法人日本抗生物質学術協議会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00218820 | |||||
関連サイト | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://www.jstage.jst.go.jp/article/antibiotics/61/2/61_94/_article/-char/ja/ | http://www.jstage.jst.go.jp/article/antibiotics/61/2/61_94/_article/-char/ja/ | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epoxyquinol B (EPQB) is a fungal metabolite, containing two ???-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues of receptor kinases. However, the inhibitory mechanism was undefined. In this report, we found that one EPQB molecule is covalently bound to two L-cysteine molecules through two epoxide residues on EPQB. Furthermore, EPQB crosslinked binding proteins through the cysteine residues. These results suggest that EPQB inhibits receptor kinases by crosslinking with other protein or by intramolecular crosslinking. | |||||
版 | ||||||
[著者版] | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2008-05-13 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A1002464 |