WEKO3
アイテム
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Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo
https://sucra.repo.nii.ac.jp/records/14473
https://sucra.repo.nii.ac.jp/records/1447393c475c9-a96a-4ea1-9321-8a53175c2756
名前 / ファイル | ライセンス | アクション |
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A3000337.pdf (2.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-06-04 | |||||
タイトル | ||||||
タイトル | Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
高田, 則雄
× 高田, 則雄× 三嶋, 恒子× 久恒, 智博× 永井, てるみ× 戎井, 悦子× 御子柴, 克彦× 平瀬, 肇 |
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著者 ローマ字 | ||||||
TANAKA, Norio | ||||||
著者 ローマ字 | ||||||
MISHIMA, Tsuneko | ||||||
著者 ローマ字 | ||||||
HISATSUNE, Chihiro | ||||||
著者 ローマ字 | ||||||
NAGAI, Terumi | ||||||
著者 ローマ字 | ||||||
EBISUI, Etsuko | ||||||
著者 ローマ字 | ||||||
MIKOSHIBA, Katsuhiko | ||||||
著者 ローマ字 | ||||||
HIRASE, Hajime | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター神経グリア回路研究チーム | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター神経グリア回路研究チーム | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター発生神経生物研究チーム | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター神経グリア回路研究チーム | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター発生神経生物研究チーム | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター発生神経生物研究チーム, 科学技術振興機構 | ||||||
著者 所属 | ||||||
理化学研究所脳科学総合研究センター神経グリア回路研究チーム, 埼玉大学脳科学融合研究センター | ||||||
著者 所属(別言語) | ||||||
Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute | ||||||
著者 所属(別言語) | ||||||
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute・ICORP-SORST JST | ||||||
著者 所属(別言語) | ||||||
Laboratory for Neuron Glia Circuit, RIKEN Brain Science Institute・Saitama University Brain Science Institute | ||||||
書誌情報 |
The Journal of Neuroscience 巻 31, 号 49, p. 18155-18165, 発行日 2011 |
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年月次 | ||||||
2011-12 | ||||||
出版者名 | ||||||
出版者 | Society for Neuroscience | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02706474 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1523/JNEUROSCI.5289-11.2011 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Global brain state dynamics regulate plasticity in local cortical circuits, but the underlying cellular and molecular mechanisms are unclear. Here, we demonstrate that astrocyte Ca2+ signaling provides a critical bridge between cholinergic activation, associated with attention and vigilance states, and somatosensory plasticity in mouse barrel cortex in vivo. We investigated first whether a combined stimulation of mouse whiskers and the nucleus basalis of Meynert (NBM), the principal source of cholinergic innervation to the cortex, leads to enhanced whisker-evoked local field potential. This plasticity is dependent on muscarinic acetylcholine receptors (mAChR) and N-methyl-d-aspartic acid receptors (NMDARs). During the induction of this synaptic plasticity, we find that astrocytic [Ca2+] is pronouncedly elevated, which is blocked by mAChR antagonists. The elevation of astrocytic [Ca2+] is crucial in this type of synaptic plasticity, as the plasticity could not be induced in inositol-1,4,5-trisphosphate receptor type 2 knock-out (IP3R2-KO) mice, in which astrocytic [Ca2+] surges are diminished. Moreover, NBM stimulation led to a significant increase in the extracellular concentration of the NMDAR coagonist d-serine in wild-type mice when compared to IP3R2-KO mice. Finally, plasticity in IP3R2-KO mice could be rescued by externally supplying d-serine. Our data present coherent lines of in vivo evidence for astrocytic involvement in cortical plasticity. These findings suggest an unexpected role of astrocytes as a gate for cholinergic plasticity in the cortex. | |||||
版 | ||||||
[出版社版] | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2012-06-06 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A3000337 |