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Activation of the rcs signal transduction system is responsible for the thermosensitive growth defect of an Escherichia coli mutant lacking phosphatidylglycerol and cardiolipin
https://sucra.repo.nii.ac.jp/records/12484
https://sucra.repo.nii.ac.jp/records/1248420d14ec1-ba32-4a15-812a-024bd5a1e7ea
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-03-08 | |||||
タイトル | ||||||
タイトル | Activation of the rcs signal transduction system is responsible for the thermosensitive growth defect of an Escherichia coli mutant lacking phosphatidylglycerol and cardiolipin | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
原, 弘志
× 原, 弘志 |
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著者 ローマ字 | ||||||
Hara, Hiroshi | ||||||
著者 ローマ字 | ||||||
Shiba, Yasuhiro | ||||||
著者 ローマ字 | ||||||
Yokoyama, Yasuko | ||||||
著者 ローマ字 | ||||||
Aono, Yoshiko | ||||||
著者 ローマ字 | ||||||
Kiuchi, Takashi | ||||||
著者 ローマ字 | ||||||
Kusaka, Jin | ||||||
著者 ローマ字 | ||||||
Matsumoto, Kouji | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科 | ||||||
著者 所属(別言語) | ||||||
Saitama University, Graduate School of Science and Engineering | ||||||
書誌情報 |
Journal of bacteriology 巻 186, 号 19, 発行日 2004 |
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年月次 | ||||||
2004 | ||||||
出版者名 | ||||||
出版者 | American Society for Microbiology | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1128/JB.186.19.6526-6535.2004 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lethal effect of the Escherichia coli pgsA null mutation which causes a complete lack of the major acidic phospholipids, phosphatidylglycerol and cardiolipin, is alleviated by the lack of the major outer membrane lipoprotein encoded by the lpp gene, but the lpp pgsA strain shows a thermosensitive growth defect. By transposon mutagenesis we found that the hermosensitivity was suppressed by disruption of the rcsC, rcsF, and yojN genes that code for sensor kinase, accessory positive factor, and phosphotransmitter, respectively, of the Rcs phosphorelay signal transduction system initially identified as regulating the capsular polysaccharide synthesis genes (cps). Disruption of the rcsB gene coding for the response regulator of the system also suppressed the thermosensitivity, whereas disruption of cpsE did not. By monitoring the expression of a cpsB′-lac fusion we showed the Rcs system was activated in the pgsA mutant and reversed to a wild-type level by the rcs mutations. These results indicate that the envelope stress due to acidic phospholipid deficiency activates the Rcs phosphorelay system and thereby causes the thermosensitive growth defect independently of the activation of capsule synthesis. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2007-03-05 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A1002021 |