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Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures
https://sucra.repo.nii.ac.jp/records/14478
https://sucra.repo.nii.ac.jp/records/14478d11352a3-eaa0-4ef4-b322-583f523dce78
名前 / ファイル | ライセンス | アクション |
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A3000423.pdf (746.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-12-14 | |||||
タイトル | ||||||
タイトル | Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HPLC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GLT-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GLAST | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | basal ganglia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cortical seizures | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
永井, てるみ
× 永井, てるみ× 高田, 則雄× 篠原, 良章× 平瀬, 肇 |
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著者 ローマ字 | ||||||
NAGAI, Terumi | ||||||
著者 ローマ字 | ||||||
TAKATA, Norio | ||||||
著者 ローマ字 | ||||||
SHINOHARA, Yoshiaki | ||||||
著者 ローマ字 | ||||||
HIRASE, Hajime | ||||||
著者 所属 | ||||||
RIKEN Brain Science Institute | ||||||
著者 所属 | ||||||
RIKEN Brain Science Institute, Department of Neuropsychiatry, School of Medicine, Keio University | ||||||
著者 所属 | ||||||
RIKEN Brain Science Institute | ||||||
著者 所属 | ||||||
RIKEN Brain Science Institute, Saitama University Brain Science Institute | ||||||
書誌情報 |
Neuroscience 巻 295, p. 229-236, 発行日 2015 |
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年月次 | ||||||
2015-6 | ||||||
出版者名 | ||||||
出版者 | Elsevier | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.neuroscience.2015.03.043 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The striatum is a major target of cerebral cortical output. The cortico-striatal projection has been well described, however, the neurochemical changes that occur in the striatum after prolonged cortical hyperactivation remain to be investigated. In this study, extracellular levels of glutamate, GABA, and alanine levels were measured in the dorsal striatum using microdialysis in anesthetized mice at resting condition and during 4-aminopyridine (4-AP)-induced cortical seizures. After topical application of 4-AP on the primary motor cortex that induced cortical seizures, the extracellular level of striatal GABA increased by 40% in sixty minutes. By contrast, the extracellular level of striatal glutamate decreased by 20%. Moreover, the surface amounts of striatal glutamate/aspartate transporter (GLAST) and glutamate transporter 1(GLT-1), the major astrocytic high-affinity glutamate transporters, tended to increase by cortical seizures in 60 min, suggesting a recruitment of the glutamate transporters from internal stores. 4-AP also resulted in a steady increase of alanine levels which are thought to reflect glutamate and pyruvate metabolism in neurons and astrocytes. These observations possibly delineate adaptive changes of striatal metabolism by severe cortical seizures. | |||||
版 | ||||||
[著者版] | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2017-12-14 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
A3000423 |