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カルボシランデンドリマー・糖鎖複合材料の開発 : 大腸菌O157の産生するベロ毒素中和剤への応用<論文>
https://doi.org/10.24561/00016076
https://doi.org/10.24561/000160760a43f591-10ae-4d90-9765-bd8dceac504f
名前 / ファイル | ライセンス | アクション |
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KY-AN00095842-38-08.pdf (1.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-07 | |||||
タイトル | ||||||
タイトル | カルボシランデンドリマー・糖鎖複合材料の開発 : 大腸菌O157の産生するベロ毒素中和剤への応用<論文> | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carbosilane dendrimer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carbohydrate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Globotriaose | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | E. Coli | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vero toxin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.24561/00016076 | |||||
ID登録タイプ | JaLC | |||||
タイトル(別言語) | ||||||
その他のタイトル | Development of Carbosilane dendrimer?Carbohydrate Composite Materials : Application for Neutralizer of Vero Toxin producing E. Coli | |||||
著者 |
幡野, 健
× 幡野, 健× 松岡, 浩司× 照沼, 大陽 |
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著者 ローマ字 | ||||||
HATANO, Ken | ||||||
著者 ローマ字 | ||||||
MATSUOKA, Koji | ||||||
著者 ローマ字 | ||||||
TERUNUMA, Daiyo | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科物質科学部門 | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科物質科学部門 | ||||||
著者 所属 | ||||||
埼玉大学大学院理工学研究科物質科学部門 | ||||||
著者 所属(別言語) | ||||||
Graduate School of Science and Engineering, Saitama University | ||||||
著者 所属(別言語) | ||||||
Graduate School of Science and Engineering, Saitama University | ||||||
著者 所属(別言語) | ||||||
Graduate School of Science and Engineering, Saitama University | ||||||
書誌情報 |
埼玉大学紀要. 工学部 第1編 第1部 論文集 en : The Science and Engineering Reports of Saitama University 巻 38, p. 40-44, 発行日 2005 |
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年月次 | ||||||
2005-3 | ||||||
出版者名 | ||||||
出版者 | 埼玉大学工学部 | |||||
出版者名(別言語) | ||||||
出版者 | Faculty of Engineering, Saitama University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18804446 | |||||
概要 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Carbosilane dendrimer periphery bearing globotiaose were synthesized by SN2 reaction of thiolate anion at aglycon of globotriaose and brominated carbosilane dendrimer. Binding assay of tree shapes of carbosilane dendrimers [Fan(0)3, Dumbbell(1)6 and Ball(1)12] were carried out. Vero toxin classified into two closely related subgroups, Stx1 and Stx2. Dumbbell(1)6 and Ball(1)12 markedly inhibited the cytotoxic activity of both Stx1 (0.22 and 0.16 μg/ml respectively) and Stx2 (2.3 and 1.3 μg/ml, respectively) toward Vero cells; whereas the IC50 of Fan(0)3 was more than 100 μg/ml. The result of the binding assay of these toxins suggested that Dumbbell(1)6 and Ball(1)12 bind to both Stx1 and Stx2 with high affinities. Furthermore, inhibitory effects of these dendrimers on the lethality of intravenously administered Stx2 in mice were investigated. Dumbbell(1)6 completely suppressed the lethal effect of Stx2 when administered along with the toxin. The dendrimer treated mice survived more than 2 months without any pathological symptoms. | |||||
その他の言語 | ||||||
言語 | eng | |||||
版 | ||||||
[出版社版] | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
作成日 | ||||||
日付 | 2008-03-07 | |||||
日付タイプ | Created | |||||
アイテムID | ||||||
KY-AN00095842-38-08 |